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Benedetto Grimaldi

Senior Researcher Tenured - Principal Investigator
Molecular Medicine
Research center

Dr. Benedetto Grimaldi obtained in 2001 the degree in Biological Science with a summa cum laude from the University of Rome “La Sapienza”.

After obtained a PhD in Genetics and Molecular Biology under the supervision of Dr. Paola Ballario (University of Rome, La Sapienza, Italy), an expert in the study of epigenetics and signal transduction, Dr. Grimaldi transitioned into a postdoctoral fellowship under the mentorship of Prof. Sassone-Corsi (University of California, Irvine, USA), a leader in the field of circadian clock, metabolism and epigenetics.

In 2011 Dr. Grimaldi joined the Drug Discovery and Development (D3) department at the Istituto Italiano di Tecnologia (IIT), where he began pursuing his own line of research focused on the study of “clock-related pathologies”, and on the identification and evaluation of novel molecules with “clock modulator” activity for therapeutic applications.

All Publications
Palomba M., Vecchio D., Allavena G., Capaccio V., De Mei C., Scarpelli R., Grimaldi B.
Identification of a Dual Autophagy and REV-ERB Inhibitor with in Vivo Anticancer Efficacy
Journal of Medicinal Chemistry, vol. 67, (no. 1), pp. 349-379
Article Journal
Kovachka S., Panosetti M., Grimaldi B., Azoulay S., Di Giorgio A., Duca M.
Small molecule approaches to targeting RNA
Nature Reviews Chemistry, vol. 8, (no. 2), pp. 120-135
Review Journal
Ugolini A., Vecchio D., Scarpelli R., Grimaldi B.
A new class of autophagy inhibitors for the treatment of cancer (P36)- September 10-13, 2023, Cambridge (United Kingdom)
XXII Medicinal Chemistry Symposium - SCI / RSC
Poster Conference
Qin Y., Ashrafizadeh M., Mongiardini V., Grimaldi B., Crea F., Rietdorf K., Gyorffy B., Klionsky D.J., Ren J., Zhang W., Zhang X.
Autophagy and cancer drug resistance in dialogue: Pre-clinical and clinical evidence
Cancer Letters, vol. 570
Scarpelli R., Palomba M., Vecchio D., Ottonello G., Mandrup Bertozzi S., Summa M., Armirotti A., Bertorelli R., De Mei C., Grimaldi B.
Identification of a dual REV-ERBβ and autophagy inhibitor with in vivo anticancer efficacy (P222)- September 3-7, 2023, Zagreb (Croatia)
IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry
Poster Conference